Manuela Baccarini

Publications

  • Hollósi A, Pászty K, Bunta BL, Bozó T, Kellermayer M, Debreczeni ML, Cervenak L, Baccarini M, Varga A. (2022) BRAF increases endothelial cell stiffness through reorganization of the actin cytoskeleton. FASEB J. e22478. doi: 10.1096/fj.202200344R.
  • Desideri, E., Castelli, S., Dorard, C., Toifl, S., Grazi, G. L., Ciriolo, M. R., and Baccarini, M. (2022) Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells. Autophagy, 1-11
  • Scheffler, L., Feicht, S., Babushku, T., Kuhn, L. B., Ehrenberg, S., Frankenberger, S., Lehmann, F. M., Hobeika, E., Jungnickel, B., Baccarini, M., Bornkamm, G. W., Strobl, L. J., and Zimber-Strobl, U. (2021) ERK phosphorylation is RAF independent in naive and activated B cells but RAF dependent in plasma cell differentiation. Sci Signal 14
  • Demiroz, D., Platanitis, E., Bryant, M., Fischer, P., Prchal-Murphy, M., Lercher, A., Lassnig, C., Baccarini, M., Muller, M., Bergthaler, A., Sexl, V., Dolezal, M., and Decker, T. (2021) Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons. PLoS Pathog 17, e1009697
  • Elgendy, M., Ciro, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M., and Minucci, S. (2019) Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3beta-MCL-1 Axis. Cancer Cell 35, 798-815 e795
  • Dorard, C., Cseh, B., Ehrenreiter, K., Wimmer, R., Varga, A., Hirschmugl, T., Maier, B., Kramer, K., Furlinger, S., Doma, E., and Baccarini, M. (2019) RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions. FEBS J 286, 2277-2294
  • Yuan, J., Ng, W. H., Tian, Z., Yap, J., Baccarini, M., Chen, Z., and Hu, J. (2018) Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis. Sci Signal 11
  • Yuan, J., Ng, W. H., Lam, P. Y. P., Wang, Y., Xia, H., Yap, J., Guan, S. P., Lee, A. S. G., Wang, M., Baccarini, M., and Hu, J. (2018) The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants. Oncogene 37, 5719-5734
  • Baumgartner, C., Toifl, S., Farlik, M., Halbritter, F., Scheicher, R., Fischer, I., Sexl, V., Bock, C., and Baccarini, M. (2018) An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell 22, 879-892 e876
  • Varga, A., Ehrenreiter, K., Aschenbrenner, B., Kocieniewski, P., Kochanczyk, M., Lipniacki, T., and Baccarini, M. (2017) RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKalpha. Sci Signal 10
  • Dorard, C., Vucak, G., and Baccarini, M. (2017) Deciphering the RAS/ERK pathway in vivo. Biochem Soc Trans 45, 27-36
  • Dorard, C., Estrada, C., Barbotin, C., Larcher, M., Garancher, A., Leloup, J., Beermann, F., Baccarini, M., Pouponnot, C., Larue, L., Eychène, A., and Druillennec, S. (2017) RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma. Nat Commun 8, 15262
  • Varga, A., and Baccarini, M. (2016) Knock-in(g) RAF for a loop. EMBO J 35, 118-120
  • Raguz, J., Jeric, I., Niault, T., Nowacka, J. D., Kuzet, S. E., Rupp, C., Fischer, I., Biggi, S., Borsello, T., and Baccarini, M. (2016) Epidermal RAF prevents allergic skin disease. eLife 5
  • Nowacka, J. D., Baumgartner, C., Pelorosso, C., Roth, M., Zuber, J., and Baccarini, M. (2016) MEK1 is required for the development of NRAS-driven leukemia. Oncotarget 7, 80113-80130
  • Liu, E. S., Raimann, A., Chae, B. T., Martins, J. S., Baccarini, M., and Demay, M. B. (2016) c-Raf promotes angiogenesis during normal growth plate maturation. Development 143, 348-355
  • Jeric, I., Gabriele, M., Cavallo, A. L., Raguz, J., Desideri, E., Tarkowski, B., Parrini, M., Fischer, I., Zatloukal, K., and Baccarini, M. (2016) A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun 7, 13781
  • Baccarini, M., and Dikic, I. (2016) Editorial overview: Cell regulation. Curr Opin Cell Biol 39, iv-vi
  • Desideri, E., Cavallo, A. L., and Baccarini, M. (2015) Alike but Different: RAF Paralogs and Their Signaling Outputs. Cell 161, 967-970
  • Vin, H., Ching, G., Ojeda, S. S., Adelmann, C. H., Chitsazzadeh, V., Dwyer, D. W., Ma, H., Ehrenreiter, K., Baccarini, M., Ruggieri, R., Curry, J. L., Ciurea, A. M., Duvic, M., Busaidy, N. L., Tannir, N. M., and Tsai, K. Y. (2014) Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK. Mol Cancer Ther 13, 221-229
  • Schneider, J. L., Suh, Y., and Cuervo, A. M. (2014) Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab 20, 417-432
  • Cseh, B., Doma, E., and Baccarini, M. (2014) "RAF" neighborhood: Protein-protein interaction in the Raf/Mek/Erk pathway. FEBS Lett 588, 2398-2406
  • Baumgartner, C., and Baccarini, M. (2014) p38 links RAS to GATA2. EMBO Rep 15, 912-913
  • Zmajkovicova, K., Jesenberger, V., Catalanotti, F., Baumgartner, C., Reyes, G., and Baccarini, M. (2013) MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance. Mol Cell 50, 43-55
  • Zeng, L., Ehrenreiter, K., Menon, J., Menard, R., Kern, F., Nakazawa, Y., Bevilacqua, E., Imamoto, A., Baccarini, M., and Rosner, M. R. (2013) RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal 25, 1156-1165
  • Vin, H., Ojeda, S. S., Ching, G., Leung, M. L., Chitsazzadeh, V., Dwyer, D. W., Adelmann, C. H., Restrepo, M., Richards, K. N., Stewart, L. R., Du, L., Ferguson, S. B., Chakravarti, D., Ehrenreiter, K., Baccarini, M., Ruggieri, R., Curry, J. L., Kim, K. B., Ciurea, A. M., Duvic, M., Prieto, V. G., Ullrich, S. E., Dalby, K. N., Flores, E. R., and Tsai, K. Y. (2013) BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling. eLife 2, e00969
  • Kern, F., Doma, E., Rupp, C., Niault, T., and Baccarini, M. (2013) Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis. Oncogene 32, 2483-2492
  • Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., Michalski, C. W., Schlitter, A. M., Esposito, I., Kind, A. J., Rad, L., Schnieke, A. E., Baccarini, M., Alessi, D. R., Rad, R., Schmid, R. M., Schneider, G., and Saur, D. (2013) Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer. Cancer Cell 23, 406-420
  • Doma, E., Rupp, C., Varga, A., Kern, F., Riegler, B., and Baccarini, M. (2013) Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK. Cancer Res 73, 6926-6937
  • Doma, E., Rupp, C., and Baccarini, M. (2013) EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers. Int J Mol Sci 14, 19361-19384
  • Wimmer, R., Cseh, B., Maier, B., Scherrer, K., and Baccarini, M. (2012) Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-alpha complex. Dev Cell 22, 158-171
  • Varga, A., and Baccarini, M. (2012) RAF-1 (C-RAF). In Encyclopedia of Signaling Molecules (Choi, S., ed) pp. 1562-1570, Springer New York
  • Valluet, A., Druillennec, S., Barbotin, C., Dorard, C., Monsoro-Burq, A. H., Larcher, M., Pouponnot, C., Baccarini, M., Larue, L., and Eychene, A. (2012) B-Raf and C-Raf are required for melanocyte stem cell self-maintenance. Cell Rep 2, 774-780
  • Bliss, S. P., Navratil, A. M., Xie, J., Miller, A., Baccarini, M., and Roberson, M. S. (2012) ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes. Endocrinology 153, 700-711
  • Schikora, A., Virlogeux-Payant, I., Bueso, E., Garcia, A. V., Niault, T., Charrier, A., Pelletier, S., Menanteau, P., Baccarini, M., Velge, P., and Hirt, H. (2011) Conservation of salmonella infection mechanisms in plants and animals. PLoS One 6, e24112
  • Maurer, G., Tarkowski, B., and Baccarini, M. (2011) Raf kinases in cancer-roles and therapeutic opportunities. Oncogene 30, 3477-3488
  • Kern, F., Niault, T., and Baccarini, M. (2011) Ras and Raf pathways in epidermis development and carcinogenesis. Br J Cancer 104, 229-234
  • Karreth, F. A., Frese, K. K., DeNicola, G. M., Baccarini, M., and Tuveson, D. A. (2011) C-Raf Is Required for the Initiation of Lung Cancer by K-RasG12D. Cancer Discovery 1, 128-136
  • Blasco, R. B., Francoz, S., Santamaría, D., Cañamero, M., Dubus, P., Charron, J., Baccarini, M., and Barbacid, M. (2011) c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 19, 652-663
  • Alejandro, E. U., Lim, G. E., Mehran, A. E., Hu, X., Taghizadeh, F., Pelipeychenko, D., Baccarini, M., and Johnson, J. D. (2011) Pancreatic beta-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J 25, 3884-3895
  • Wimmer, R., and Baccarini, M. (2010) Partner exchange: protein-protein interactions in the Raf pathway. Trends Biochem Sci 35, 660-668
  • Niault, T. S., and Baccarini, M. (2010) Targets of Raf in tumorigenesis. Carcinogenesis 31, 1165-1174
  • Galabova-Kovacs, G., and Baccarini, M. (2010) Deciphering Signaling Pathways In Vivo: The Ras/Raf/Mek/Erk Cascade. In MAP Kinase Signaling Protocols: Second Edition (Seger, R., ed) pp. 421-431, Humana Press, Totowa, NJ
  • De Andrea, M., Ritta, M., Landini, M. M., Borgogna, C., Mondini, M., Kern, F., Ehrenreiter, K., Baccarini, M., Marcuzzi, G. P., Smola, S., Pfister, H., Landolfo, S., and Gariglio, M. (2010) Keratinocyte-specific stat3 heterozygosity impairs development of skin tumors in human papillomavirus 8 transgenic mice. Cancer Res 70, 7938-7948
  • Niault, T., Sobczak, I., Meissl, K., Weitsman, G., Piazzolla, D., Maurer, G., Kern, F., Ehrenreiter, K., Hamerl, M., Moarefi, I., Leung, T., Carugo, O., Ng, T., and Baccarini, M. (2009) From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol 187, 335-342
  • Ehrenreiter, K., Kern, F., Velamoor, V., Meissl, K., Galabova-Kovacs, G., Sibilia, M., and Baccarini, M. (2009) Raf-1 addiction in Ras-induced skin carcinogenesis. Cancer Cell 16, 149-160
  • Catalanotti, F., Reyes, G., Jesenberger, V., Galabova-Kovacs, G., de Matos Simoes, R., Carugo, O., and Baccarini, M. (2009) A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol 16, 294-303
  • Telci, D., Wang, Z., Li, X., Verderio, E. A., Humphries, M. J., Baccarini, M., Basaga, H., and Griffin, M. (2008) Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem 283, 20937-20947
  • Sobczak, I., Galabova-Kovacs, G., Sadzak, I., Kren, A., Christofori, G., and Baccarini, M. (2008) B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis. Oncogene 27, 4779-4787
  • Galabova-Kovacs, G., Catalanotti, F., Matzen, D., Reyes, G. X., Zezula, J., Herbst, R., Silva, A., Walter, I., and Baccarini, M. (2008) Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol 180, 947-955
  • Edelblum, K. L., Washington, M. K., Koyama, T., Robine, S., Baccarini, M., and Polk, D. B. (2008) Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology 135, 539-551
  • Zhong, J., Li, X., McNamee, C., Chen, A. P., Baccarini, M., and Snider, W. D. (2007) Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci 10, 598-607
  • Matallanas, D., Romano, D., Yee, K., Meissl, K., Kucerova, L., Piazzolla, D., Baccarini, M., Vass, J. K., Kolch, W., and O'Neill, E. (2007) RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell 27, 962-975
  • Rubiolo, C., Piazzolla, D., Meissl, K., Beug, H., Huber, J. C., Kolbus, A., and Baccarini, M. (2006) A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. Blood 108, 152-159
  • Galabova-Kovacs, G., Matzen, D., Piazzolla, D., Meissl, K., Plyushch, T., Chen, A. P., Silva, A., and Baccarini, M. (2006) Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A 103, 1325-1330
  • Galabova-Kovacs, G., Kolbus, A., Matzen, D., Meissl, K., Piazzolla, D., Rubiolo, C., Steinitz, K., and Baccarini, M. (2006) ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts. Cell Cycle 5, 1514-1518
  • Piazzolla, D., Meissl, K., Kucerova, L., Rubiolo, C., and Baccarini, M. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J Cell Biol 171, 1013-1022
  • Ehrenreiter, K., Piazzolla, D., Velamoor, V., Sobczak, I., Small, J. V., Takeda, J., Leung, T., and Baccarini, M. (2005) Raf-1 regulates Rho signaling and cell migration. J Cell Biol 168, 955-964
  • Baccarini, M. (2005) Second nature: biological functions of the Raf-1 "kinase". FEBS Lett 579, 3271-3277
  • Yamaguchi, O., Watanabe, T., Nishida, K., Kashiwase, K., Higuchi, Y., Takeda, T., Hikoso, S., Hirotani, S., Asahi, M., Taniike, M., Nakai, A., Tsujimoto, I., Matsumura, Y., Miyazaki, J., Chien, K. R., Matsuzawa, A., Sadamitsu, C., Ichijo, H., Baccarini, M., Hori, M., and Otsu, K. (2004) Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest 114, 937-943
  • O'Neill, E., Rushworth, L., Baccarini, M., and Kolch, W. (2004) Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306, 2267-2270
  • Karaghiosoff, M., Steinborn, R., Kovarik, P., Kriegshauser, G., Baccarini, M., Donabauer, B., Reichart, U., Kolbe, T., Bogdan, C., Leanderson, T., Levy, D., Decker, T., and Muller, M. (2003) Central role for type I interferons and Tyk2 in lipopolysaccharide- induced endotoxin shock. Nat Immunol 4, 471-477.
  • Rovida, E., Baccarini, M., Olivotto, M., and Sbarba, P. D. (2002) Opposite effects of different doses of MCSF on ERK phosphorylation and cell proliferation in macrophages. Oncogene 21, 3670-3676.
  • Kubicek, M., Pacher, M., Abraham, D., Podar, K., Eulitz, M., and Baccarini, M. (2002) Dephosphorylation of Ser-259 regulates Raf-1 membrane association. J Biol Chem 277, 7913-7919
  • Kolbus, A., Pilat, S., Husak, Z., Deiner, E. M., Stengl, G., Beug, H., and Baccarini, M. (2002) Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation. J. Exp. Med. 196, 1347-1353
  • Baccarini, M. (2002) An old kinase on a new path: Raf and apoptosis. Cell Death Differ 9, 783-785.
  • Mikula, M., Schreiber, M., Husak, Z., Kucerova, L., Ruth, J., Wieser, R., Zatloukal, K., Beug, H., Wagner, E. F., and Baccarini, M. (2001) Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J 20, 1952-1962
  • Jesenberger, V., Procyk, K. J., Ruth, J., Schreiber, M., Theussl, H. C., Wagner, E. F., and Baccarini, M. (2001) Protective role of Raf-1 in Salmonella-induced macrophage apoptosis. J Exp Med 193, 353-364
  • Rovida, E., Marra, F., Baccarini, M., and Dello Sbarba, P. (2000) Constitutive activation of the MAPK pathway mediates v-fes-induced mitogenesis in murine macrophages. Blood 95, 3959-3963
  • Procyk, K. J., Rippo, M. R., Testi, R., Hofmann, F., Parker, P. J., and Baccarini, M. (2000) Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine- dependent phospholipase C [In Process Citation]. Blood 96, 2592-2598
  • Jesenberger, V., Procyk, K. J., Yuan, J., Reipert, S., and Baccarini, M. (2000) Salmonella-induced Caspase-2 Activation in Macrophages. A novel mechanism in pathogen-mediated apoptosis. J Exp Med 192, 1035-1046
  • Janosch, P., Kieser, A., Eulitz, M., Lovric, J., Sauer, G., Reichert, M., Gounari, F., Buscher, D., Baccarini, M., Mischak, H., and Kolch, W. (2000) The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments. Faseb J 14, 2008-2021
  • Abraham, D., Podar, K., Pacher, M., Kubicek, M., Welzel, N., Hemmings, B. A., Dilworth, S. M., Mischak, H., Kolch, W., and Baccarini, M. (2000) Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation. J Biol Chem 275, 22300-22304
  • Procyk, K. J., Rippo, M. R., Testi, R., Hoffmann, F., Parker, P. J., and Baccarini, M. (1999) Distinct Mechanisms Target Stress and Extracellular Signal-Activated Kinase 1 and Jun N-Terminal Kinase During Infection of Macrophages with Salmonella. J Immunol 163, 4924-4930
  • Procyk, K. J., Kovarik, P., von Gabain, A., and Baccarini, M. (1999) Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. Infect Immun 67, 1011-1017
  • Morice, C., Nothias, F., S, K. n., Vernier, P., Baccarini, M., Vincent, J. D., and Barnier, J. V. (1999) Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain. Eur J Neurosci 11, 1995-2006
  • Lundberg, U., Vinatzer, U., Berdnik, D., von Gabain, A., and Baccarini, M. (1999) Growth phase-regulated induction of Salmonella-induced macrophage apoptosis correlates with transient expression of SPI-1 genes. J Bacteriol 181, 3433-3437
  • Vytvytska, O., Jakobsen, J. S., Balcunaite, G., Andersen, J. S., Baccarini, M., and von Gabain, A. (1998) Host factor I, Hfq, binds to Escherichia coli ompA mRNA in a growth rate-dependent fashion and regulates its stability. Proc Natl Acad Sci U S A 95, 14118-14123
  • Ambs, P., Baccarini, M., Schwende, H., Fitzke, E., and Dieter, P. (1997) Regulation of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages. Adv Exp Med Biol 407, 479-483
  • Laker, C., Friel, J., Franz, M.-J., Baccarini, M., Ostertag, W., and Stocking, C. (1996) Altered Growth Factor Response in Myeloid Progenitor Cell Mutants Derived after Retroviral Insertlonal Mutagenesis. In Gene Technology pp. 307-319, Springer Berlin Heidelberg
  • Krautwald, S., Buscher, D., Kummer, V., Buder, S., and Baccarini, M. (1996) Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway. Mol Cell Biol 16, 5955-5963
  • Krautwald, S., Buscher, D., Dent, P., Ruthenberg, K., and Baccarini, M. (1995) Suppression of growth factor-mediated MAP kinase activation by v-raf in macrophages: a putative role for the MKP-1 phosphatase. Oncogene 10, 1187-1192
  • Buscher, D., Hipskind, R. A., Krautwald, S., Reimann, T., and Baccarini, M. (1995) Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol Cell Biol 15, 466-475
  • Ambs, P., Baccarini, M., Fitzke, E., and Dieter, P. (1995) Role of cytosolic phospholipase A2 in arachidonic acid release of rat- liver macrophages: regulation by Ca2+ and phosphorylation. Biochem J 311, 189-195
  • Reimann, T., Buscher, D., Hipskind, R. A., Krautwald, S., Lohmann-Matthes, M. L., and Baccarini, M. (1994) Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes. J Immunol 153, 5740-5749
  • Li, H., Pohler, U., Strehlow, I., Hertig, S., Baccarini, M., Emmendorffer, A., Tschopp, J., and Lohmann-Matthes, M. L. (1994) Macrophage precursor cells produce perforin and perform Yac-1 lytic activity in response to stimulation with interleukin-2. J Leukoc Biol 56, 117-123
  • Hipskind, R. A., Buscher, D., Nordheim, A., and Baccarini, M. (1994) Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors. Genes Dev 8, 1803-1816
  • Hipskind, R. A., Baccarini, M., and Nordheim, A. (1994) Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo. Mol Cell Biol 14, 6219-6231
  • Heusohn, F., Pohler, U., Decker, T., Just, U., Ostertag, W., Lohmann-Matthes, M. L., and Baccarini, M. (1994) Coordinate expression of the lineage-specific growth factor colony-stimulating factor (CSF)-1 and its receptor selectively promotes macrophage maturation during differentiation of multipotential progenitor cells. Cell Growth Differ 5, 1119-1126
  • Eilers, A., Baccarini, M., Horn, F., Hipskind, R. A., Schindler, C., and Decker, T. (1994) A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site. Mol Cell Biol 14, 1364-1373
  • Krautwald, S., and Baccarini, M. (1993) Bacterially expressed murine CSF-1 possesses agonistic activity in its monomeric form. Biochem Biophys Res Commun 192, 720-727
  • Just, U., Friel, J., Heberlein, C., Tamura, T., Baccarini, M., Tessmer, U., Klingler, K., and Ostertag, W. (1993) Upregulation of lineage specific receptors and ligands in multipotential progenitor cells is part of an endogenous program of differentiation. Growth Factors 9, 291-300
  • Eilers, A., Seegert, D., Schindler, C., Baccarini, M., and Decker, T. (1993) The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage. Mol Cell Biol 13, 3245-3254
  • Buscher, D., Dello Sbarba, P., Hipskind, R. A., Rapp, U. R., Stanley, E. R., and Baccarini, M. (1993) v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation. Oncogene 8, 3323-3332
  • Baccarini, M., Dello Sbarba, P., Buscher, D., Bartocci, A., and Stanley, E. R. (1992) IFN-gamma/lipopolysaccharide activation of macrophages is associated with protein kinase C-dependent down-modulation of the colony- stimulating factor-1 receptor. J Immunol 149, 2656-2661
  • Baccarini, M., Li, W., Sbarba, P. D., and Stanley, E. R. (1991) Increased phosphorylation of the colony stimulating factor-1 receptor following transmembrane signaling. Receptor 1, 243-259
  • Baccarini, M., Gill, G. N., and Stanley, E. R. (1991) Epidermal growth factor stimulates phosphorylation of RAF-1 independently of receptor autophosphorylation and internalization. J Biol Chem 266, 10941-10945
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  • Bistoni, F., Baccarini, M., Scaringi, L., Mazzolla, R., Puccetti, P., and Marconi, P. (1985) Modulating effects of thymic factors in normal and cyclophosphamide-treated mice. In Genetic and phenotypic markers of tumors. (Aaronson, S. A., Frati, L., and Verna, R., eds) p. 139
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  • Baccarini, M., Vecchiarelli, A., Cassone, A., and Bistoni, F. (1985) Killing of yeast, germ-tube and mycelial forms of Candida albicans by murine effectors as measured by a radiolabel release microassay. J Gen Microbiol 131, 505-513
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  • Bistoni, F., Baccarini, M., Blasi, E., Marconi, P., Puccetti, P., and Garaci, E. (1983) Correlation between in vivo and in vitro studies of modulation of resistance to experimental Candida albicans infection by cyclophosphamide in mice. Infect Immun 40, 46-55
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  • Favalli, C., Baccarini, M., Blasi, E., Bevilacqua, R., Rinaldi, C., and Mastroviti, F. (1981) [Cell wall skeletons of Candida albicans and micrococci as antitumor immunoadjuvants]. Boll Soc Ital Biol Sper 57, 1911-1915
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